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Although our name and logo may be changing, you can continue to expect the same quality, access and personal service that you have come to know and trust. The patient-centered medical home (PCMH) is an approach to delivering comprehensive, continuous, coordinated care across all life stages and has been hypothesized to be one potential solution to the discrepancy between the high cost but low quality of health care in the US.

Although a plethora of literature exists on how pharmacy interventions can improve the quality of patient care through medication therapy management programs, there is a paucity of data supporting pharmacists’ involvement in PCMHs. Pharmacists are uniquely trained and positioned to make important contributions to PCMHs as medication care coordinators.

The opportunity is now for pharmacists to establish their role within this medical setting. DATA SYNTHESIS: Fospropofol is a water-soluble prodrug of propofol, a potent sedative–hypnotic agent.

Propofol is highly lipophilic and is formulated in lipid-containing solvents, which have known disadvantages, including pain on injection, narrow therapeutic window with the potential to cause deep sedation, high lipid intake during long-term sedation, and risk of infection resulting from bacterial contamination. Due to its water solubility, fospropofol eliminates some of the known lipid emulsion–associated disadvantages of propofol and provides a more predictable peak onset of activity and more gradual recovery to a full state of consciousness.

The pharmacokinetic and pharmacodynamic profiles of fospropofol make it an attractive agent for sedation for procedures of short duration. Unfortunately, the number of patients studied has been relatively small and the amount of safety data is limited.

Of concern are reports of hypoxemia and hypotension; these reports are limited in number, but the episodes are serious and may require acute intervention. Although fospropofol holds promise for procedural sedation, due to limited safety data, the Food and Drug Administration has limited approval of fospropofol to monitored anesthesia care in patients undergoing diagnostic or therapeutic procedures.

CONCLUSIONS: Fospropofol is a viable addition to the class of sedative–hypnotic agents due to the minimization of unwanted adverse effects of propofol and maintenance of a favorable pharmacokinetic profile facilitating sedation, anxiolysis, and rapid recovery. However, there are limited safety data to justify its use without the presence of dedicated anesthesia personnel.

Synthetica is located in Oslo Research Park and is an efficient,flexible and independent synthesis laboratory. Our staff is capable of handling complex synthetic assignments and providing high quality, on-time, and confidential services.